An evaluation of a preparation of Mycobacterium vaccae (SRL172) as an immunotherapeutic agent in renal cancer
Identifieur interne : 008E82 ( Main/Exploration ); précédent : 008E81; suivant : 008E83An evaluation of a preparation of Mycobacterium vaccae (SRL172) as an immunotherapeutic agent in renal cancer
Auteurs : P. M. Patel [Royaume-Uni] ; S. Sim [Royaume-Uni] ; D. O. O'Donnell [Irlande (pays)] ; A. Protheroe [Royaume-Uni] ; D. Beirne [Royaume-Uni] ; A. Stanley [Royaume-Uni] ; J. M. Tourani [France] ; D. Khayat [France] ; B. Hancock [Royaume-Uni] ; P. Vasey [Australie] ; A. Dalgleish [Royaume-Uni] ; C. Johnston [Royaume-Uni] ; R. E. Banks [Royaume-Uni] ; P. J. Selby [Royaume-Uni]Source :
- European journal of cancer : (1990) [ 0959-8049 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Pharmacologie.
English descriptors
- KwdEn :
Abstract
Two studies were carried out to evaluate heat-killed Mycobacterium uaccae SRL172 as an immunotherapeutic agent for patients with metastatic, post-nephrectomy, renal cell carcinoma. In the first study, 60 patients in France and the UK received injections of SRL172, and their survival was compared with that of historical controls who had been treated either with biological response modifiers (IL-2, IFN-α) or chemotherapy. In the second study, 36 patients were randomised to receive treatment with IL-2 alone or IL-2 plus SRL172. Survival and adverse events related to the treatments were assessed and compared between treatment groups. The first study showed that those treated with SRL172 alone survived equally as long as those receiving IL-2 or IFN-α and both treatment groups survived longer than those on chemotherapy < 0.001), a result supported by Cox's proportional hazards regression analysis. The second study, stopped early due to drug supply issues, showed that the addition of SRL172 to IL-2 made no difference to survival compared to IL-2 alone, in the limited numbers treated. Adverse events occurring in those receiving SRL172 in the first study were mild and in the second study those receiving IL-2 alone had significantly more adverse events than those receiving SRL172 plus IL-2 (p < 0.001). It is concluded that SRL172 may have activity in metastatic renal cancer and has very low toxicity, making it worthy of further study.
Affiliations:
- Australie, France, Irlande (pays), Royaume-Uni
- Angleterre, Grand Londres, Nottinghamshire, Nouvelle-Aquitaine, Oxfordshire, Poitou-Charentes, Île-de-France
- Londres, Nottingham, Oxford, Paris, Poitiers
- Université de Nottingham
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">An evaluation of a preparation of Mycobacterium vaccae (SRL172) as an immunotherapeutic agent in renal cancer</title><author><name sortKey="Patel, P M" sort="Patel, P M" uniqKey="Patel P" first="P. M." last="Patel">P. M. Patel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Academic Division of Clinical Oncology, University of Nottingham, Nottingham University Hospitals -City Campus</s1><s2>Nottingham NG51PB</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Nottingham NG51PB</wicri:noRegion><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Sim, S" sort="Sim, S" uniqKey="Sim S" first="S." last="Sim">S. Sim</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, D O" sort="O Donnell, D O" uniqKey="O Donnell D" first="D. O." last="O'Donnell">D. O. O'Donnell</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Haematology Oncology Care Centre, St. James's Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>3 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Protheroe, A" sort="Protheroe, A" uniqKey="Protheroe A" first="A." last="Protheroe">A. 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Khayat</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Oncology, Salpetriere Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hancock, B" sort="Hancock, B" uniqKey="Hancock B" first="B." last="Hancock">B. Hancock</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>orkshire Cancer Research Academic Unit of Clinical Oncology, Weston Park Hospital</s1><s2>Sheffield</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Vasey, P" sort="Vasey, P" uniqKey="Vasey P" first="P." last="Vasey">P. Vasey</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>University of Queensland, Division of Medicine</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Dalgleish, A" sort="Dalgleish, A" uniqKey="Dalgleish A" first="A." last="Dalgleish">A. Dalgleish</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Division of Oncology, St. George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Johnston, C" sort="Johnston, C" uniqKey="Johnston C" first="C." last="Johnston">C. Johnston</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Banks, R E" sort="Banks, R E" uniqKey="Banks R" first="R. E." last="Banks">R. E. Banks</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Selby, P J" sort="Selby, P J" uniqKey="Selby P" first="P. J." last="Selby">P. J. Selby</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0123454</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0123454 INIST</idno><idno type="RBID">Pascal:08-0123454</idno><idno type="wicri:Area/PascalFrancis/Corpus">003723</idno><idno type="wicri:Area/PascalFrancis/Curation">002916</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003418</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003418</idno><idno type="wicri:doubleKey">0959-8049:2008:Patel P:an:evaluation:of</idno><idno type="wicri:Area/Main/Merge">009832</idno><idno type="wicri:Area/Main/Curation">008E82</idno><idno type="wicri:Area/Main/Exploration">008E82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">An evaluation of a preparation of Mycobacterium vaccae (SRL172) as an immunotherapeutic agent in renal cancer</title><author><name sortKey="Patel, P M" sort="Patel, P M" uniqKey="Patel P" first="P. M." last="Patel">P. M. Patel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Academic Division of Clinical Oncology, University of Nottingham, Nottingham University Hospitals -City Campus</s1><s2>Nottingham NG51PB</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Nottingham NG51PB</wicri:noRegion><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Sim, S" sort="Sim, S" uniqKey="Sim S" first="S." last="Sim">S. Sim</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="O Donnell, D O" sort="O Donnell, D O" uniqKey="O Donnell D" first="D. O." last="O'Donnell">D. O. O'Donnell</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Haematology Oncology Care Centre, St. James's Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>3 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Protheroe, A" sort="Protheroe, A" uniqKey="Protheroe A" first="A." last="Protheroe">A. Protheroe</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Cancer Research UK, Department of Medical Oncology, Churchill Hospital</s1><s2>Oxford</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Beirne, D" sort="Beirne, D" uniqKey="Beirne D" first="D." last="Beirne">D. Beirne</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Stanley, A" sort="Stanley, A" uniqKey="Stanley A" first="A." last="Stanley">A. Stanley</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Tourani, J M" sort="Tourani, J M" uniqKey="Tourani J" first="J. M." last="Tourani">J. M. Tourani</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Medical Oncology Unit, CHU de Poitiers</s1><s2>Poitiers</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName></affiliation></author><author><name sortKey="Khayat, D" sort="Khayat, D" uniqKey="Khayat D" first="D." last="Khayat">D. Khayat</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Oncology, Salpetriere Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hancock, B" sort="Hancock, B" uniqKey="Hancock B" first="B." last="Hancock">B. Hancock</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>orkshire Cancer Research Academic Unit of Clinical Oncology, Weston Park Hospital</s1><s2>Sheffield</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Vasey, P" sort="Vasey, P" uniqKey="Vasey P" first="P." last="Vasey">P. Vasey</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>University of Queensland, Division of Medicine</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Dalgleish, A" sort="Dalgleish, A" uniqKey="Dalgleish A" first="A." last="Dalgleish">A. Dalgleish</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Division of Oncology, St. George's Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Johnston, C" sort="Johnston, C" uniqKey="Johnston C" first="C." last="Johnston">C. Johnston</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Banks, R E" sort="Banks, R E" uniqKey="Banks R" first="R. E." last="Banks">R. E. Banks</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Selby, P J" sort="Selby, P J" uniqKey="Selby P" first="P. J." last="Selby">P. J. Selby</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street</s1><s2>Leeds</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">European journal of cancer : (1990)</title><title level="j" type="abbreviated">Eur. j. cancer : (1990)</title><idno type="ISSN">0959-8049</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">European journal of cancer : (1990)</title><title level="j" type="abbreviated">Eur. j. cancer : (1990)</title><idno type="ISSN">0959-8049</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term><term>Carcinoma</term><term>Grawitz tumor</term><term>Immunotherapy</term><term>Kidney cancer</term><term>Mycobacterium vaccae</term><term>Pharmacology</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cancer rein</term><term>Mycobacterium vaccae</term><term>Traitement</term><term>Hypernéphrome</term><term>Cancérologie</term><term>Pharmacologie</term><term>Immunothérapie</term><term>Carcinome</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Pharmacologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two studies were carried out to evaluate heat-killed Mycobacterium uaccae SRL172 as an immunotherapeutic agent for patients with metastatic, post-nephrectomy, renal cell carcinoma. In the first study, 60 patients in France and the UK received injections of SRL172, and their survival was compared with that of historical controls who had been treated either with biological response modifiers (IL-2, IFN-α) or chemotherapy. In the second study, 36 patients were randomised to receive treatment with IL-2 alone or IL-2 plus SRL172. Survival and adverse events related to the treatments were assessed and compared between treatment groups. The first study showed that those treated with SRL172 alone survived equally as long as those receiving IL-2 or IFN-α and both treatment groups survived longer than those on chemotherapy < 0.001), a result supported by Cox's proportional hazards regression analysis. The second study, stopped early due to drug supply issues, showed that the addition of SRL172 to IL-2 made no difference to survival compared to IL-2 alone, in the limited numbers treated. Adverse events occurring in those receiving SRL172 in the first study were mild and in the second study those receiving IL-2 alone had significantly more adverse events than those receiving SRL172 plus IL-2 (p < 0.001). It is concluded that SRL172 may have activity in metastatic renal cancer and has very low toxicity, making it worthy of further study.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Irlande (pays)</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Nottinghamshire</li><li>Nouvelle-Aquitaine</li><li>Oxfordshire</li><li>Poitou-Charentes</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Nottingham</li><li>Oxford</li><li>Paris</li><li>Poitiers</li></settlement><orgName><li>Université de Nottingham</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Patel, P M" sort="Patel, P M" uniqKey="Patel P" first="P. M." last="Patel">P. M. Patel</name></region><name sortKey="Banks, R E" sort="Banks, R E" uniqKey="Banks R" first="R. E." last="Banks">R. E. Banks</name><name sortKey="Beirne, D" sort="Beirne, D" uniqKey="Beirne D" first="D." last="Beirne">D. Beirne</name><name sortKey="Dalgleish, A" sort="Dalgleish, A" uniqKey="Dalgleish A" first="A." last="Dalgleish">A. Dalgleish</name><name sortKey="Hancock, B" sort="Hancock, B" uniqKey="Hancock B" first="B." last="Hancock">B. Hancock</name><name sortKey="Johnston, C" sort="Johnston, C" uniqKey="Johnston C" first="C." last="Johnston">C. Johnston</name><name sortKey="Protheroe, A" sort="Protheroe, A" uniqKey="Protheroe A" first="A." last="Protheroe">A. Protheroe</name><name sortKey="Selby, P J" sort="Selby, P J" uniqKey="Selby P" first="P. J." last="Selby">P. J. Selby</name><name sortKey="Sim, S" sort="Sim, S" uniqKey="Sim S" first="S." last="Sim">S. Sim</name><name sortKey="Stanley, A" sort="Stanley, A" uniqKey="Stanley A" first="A." last="Stanley">A. Stanley</name></country><country name="Irlande (pays)"><noRegion><name sortKey="O Donnell, D O" sort="O Donnell, D O" uniqKey="O Donnell D" first="D. O." last="O'Donnell">D. O. O'Donnell</name></noRegion></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Tourani, J M" sort="Tourani, J M" uniqKey="Tourani J" first="J. M." last="Tourani">J. M. Tourani</name></region><name sortKey="Khayat, D" sort="Khayat, D" uniqKey="Khayat D" first="D." last="Khayat">D. Khayat</name></country><country name="Australie"><noRegion><name sortKey="Vasey, P" sort="Vasey, P" uniqKey="Vasey P" first="P." last="Vasey">P. Vasey</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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